When I \u00a0saw this posting, my first thought was to be sure that it was not April first. While I still harbor a measure of skepticism, as I believe genetics still have a long way to go before the science matures; I am intrigued and amused. Of course it is a perfect explanation\/excuse for my behavior over the past 45 years.<\/p>\n
Scientists find gene for love of the sea<\/strong><\/p>\n Posted on March 8, 2011<\/a> by genotopia<\/a><\/p>\n What did Thor Heyerdahl, Captain Ahab, and Odysseus have in common? They all may have shared a common variant of a gene for love of the sea.<\/p>\n Researchers at Mystic University in Connecticut have identified a gene associated with seafaringness, according to an article to be published tomorrow in the journal\u00a0Genetic Determinism Today<\/em>. Patterns of inheritance of the long-sought gene offers hope for \u201csailing widows,\u201d and could help explain why the sailing life has tended to run in families and why certain towns and geographical regions tend historically to have disproportionate numbers of sea-going citizens.<\/p>\n The gene is a form of the MAOA-L gene, previously associated with high-risk behavior and thrill-seeking; another form of the gene, found last year, made news as the \u201cwarrior gene<\/a>.\u201d The current variant, dubbed 4C, was found by a genome-wide association study (GWAS) on 290 individuals from Mystic, CT, New Bedford, MA, and Cold Spring Harbor, NY\u2014all traditional nineteenth-century whaling villages. Residents showed the presence of the 4C variant at a frequency more than 20 times above background in neighboring landlocked towns.<\/p>\n C. M. Ishmael, the lead researcher on the study, said the findings could be a boon to medicine. Although the International Whaling Commission outlawed commercial whaling in 1986, the research could benefit literally hundreds of \u201csailing widows\u201d left alone for Wednesday-evening sailboat races up and down the East Coast. Each year, an average of 11 salt-stained Polo shirts washes up on the New England and Mid-Atlantic coasts, the only remains of a lantern-jawed investment banker and his half-million-dollar boat. Ishmael said he is trying to have the irrational urge to sail entered into the Diagnostic and Statistical Manual<\/em><\/a>, standard reference for psychiatric diseases, in the next, fifth, edition.<\/p>\n \u201cThis receptor is an exciting potential target for new drug therapies,\u201d Ishmael said in a phone interview. \u201cWe hope lots of companies will be interested in it. And venture capital, too.\u201d Ishmael is himself CEO of a company, MysticGene, formed to develop such therapies. When asked about potential conflict of interest, he replied cryptically, \u201cWell, duh.\u201d Shares of MysticGene closed higher on Monday following the announcement.<\/p>\n The gene for seafaringness has long been an object of study for human geneticists. The trait was first described in 1919<\/a> by Charles Davenport, director of Cold Spring Harbor Laboratory, who named it \u201cthalassophilia.\u201d Using pedigree analysis and anecdotal correlation, Davenport identified thalassophilia as a sex-linked recessive gene and distinguished it clinically from wanderlust, or love of adventure. Although one might think naively that people living in towns with good harbors would tend to go to sea, Davenport suggested the reverse: those with the thalassophilia trait have tended to migrate toward regions with good harbors and found settlements there. The current study does nothing to refute Davenport\u2019s analysis.<\/p>\n Further, a tentative expansion of the GWAS analysis to various racial groups largely confirms Davenport\u2019s observations that thalassophilia is more prevalent in Scandinavians and the English, and less common in people of German ancestry.<\/p>\n Thalassophilia joins a rapidly growing list of complex behavioral traits that have been shown to have a genetic basis, thanks to GWAS. Besides the warrior gene, recent studies have found genetic links to promiscuity<\/a>, aggressive behavior, especially while drinking<\/a>, religiosity<\/a>, and bipolar disorder<\/a>, or manic depression\u2014all traits that Davenport and other early human geneticists were deeply interested in. The difference is that modern science better understands the mechanisms involved.<\/p>\n \u201cSeamen know very well that their cravings for the sea are racial,\u201d Davenport wrote in 1919. \u201c\u2019It is in the blood,\u2019 they say.\u201d Today we know it\u2019s not in the blood\u2014it\u2019s in the genes.<\/p>\n The true bits:<\/em><\/p>\n Garland E. Allen, \u201cIs a New Eugenics Afoot?,\u201d\u00a0Science<\/em> 294, no. 5540 (October 5, 2001): 59 -61. (http:\/\/www.sciencemag.org\/content\/294\/5540\/59.short<\/a>)<\/p>\n Charles Benedict Davenport and Mary Theresa Scudder,\u00a0Naval officers: their heredity and development<\/em> (Carnegie Institution of Washington, 1919),http:\/\/books.google.com\/books?id=EWESAAAAYAAJ&dq=naval%20officers%3A%20their%20heredity%20and%20development&pg=PP1#v=onepage&q&f=false<\/a>.<\/p>\n Richard Alleyne, \u201cA gene that could explain why the red mist descends,\u201d\u00a0Telegraph.co.uk<\/em>,http:\/\/www.telegraph.co.uk\/science\/science-news\/8219521\/A-gene-that-could-explain-why-the-red-mist-descends.html<\/a>.<\/p>\n Jeremy Taylor, \u201cViolent-drunk gene discovered,\u201dhttp:\/\/www.asylum.com\/2010\/12\/23\/bad-drunk-gene-discovered\/<\/a>.<\/p>\n Justin R. Garcia et al., \u201cAssociations between Dopamine D4 Receptor Gene Variation with Both Infidelity and Sexual Promiscuity,\u201d ed. Jan Lauwereyns,\u00a0PLoS ONE<\/em> 5, no. 11 (11, 2010): e14162.<\/p>\n C. Frydman et al., \u201cMAOA-L carriers are better at making optimal financial decisions under risk,\u201d\u00a0Proceedings of the Royal Society B: Biological Sciences<\/em> (12, 2010),http:\/\/www.newscientist.com\/article\/dn19830-people-with-warrior-gene-better-<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" When I \u00a0saw this posting, my first thought was to be sure that it was not April first. While I still harbor a measure of skepticism, as I believe genetics still have a long way to go before the science matures; I am intrigued and amused. Of course it is a perfect explanation\/excuse for my … Continue reading LOVE OF THE SEA<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[491],"tags":[642,643],"class_list":["post-1357","post","type-post","status-publish","format-standard","hentry","category-sailing","tag-genetics","tag-seafaring"],"_links":{"self":[{"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=\/wp\/v2\/posts\/1357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1357"}],"version-history":[{"count":1,"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=\/wp\/v2\/posts\/1357\/revisions"}],"predecessor-version":[{"id":1358,"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=\/wp\/v2\/posts\/1357\/revisions\/1358"}],"wp:attachment":[{"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stephenlirakis.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}